Chemours is cutting 400 employees from its workforce.
The Wilmington-based company says about 50 of those layoffs will be in Delaware.
The company currently has around 1,100 employees in the First State.
The move comes after the DuPont spinoff reported last month it lost $29 million in the third quarter.
It also follows Chemours decision in August to shutter its longtime plant at Edge Moor in North Wilmington – which was home to 200 employees and 130 contractors.
The biggest cut in this latest round of layoffs will come in New York where the company is shutting down its a plant in Niagara where about 200 employees and contractors work.
The company says it expects to save 50 millions dollars with the cuts, which it says will be completed in 2016