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The Middle East reacts to the U.S.-Israeli attacks on Iran which killed Supreme Leader Ayatollah Ali Khamenei.

NPR's Ayesha Rascoe speaks to Ray Takeyh, senior fellow for Middle East studies at the Council on Foreign Relations, about possible outcomes now that the U.S. and Israel have attacked Iran.

NPR's Ayesha Rascoe talks with Mary Lovely of the Peterson Institute for International Economics about what military action in Iran – and Tehran's response – could mean for the global economy.

President Trump delivered on his threat to strike Iran and announced a military campaign there on Saturday assisted by Israel. He also called for regime change.

Some writers have a designated desk or a curated room where they work. Others write anywhere and everywhere. Katie da Cunha Lewin examines famous authors' spaces in her new book, "The Writer's Room."

The Messthetics and James Brandon Lewis intersect punk and jazz on their second collaborative effort as a quartet, "Deface the Currency."

NPR's Ayesha Rascoe plays the puzzle with WXXI listener Jonathan Black and Weekend Edition Puzzlemaster Will Shortz.

The deaths of three U.S. service members mark the first American casualties since the start of operation "Epic Fury" on Saturday. President Trump said "there will likely be more" Americans killed.

The Iranian government has announced 40 days of mourning. The country's supreme leader was killed following an attack launched by the U.S. and Israel on Saturday against Iran.

Iran fired missiles at targets in Israel and Gulf Arab states Sunday after vowing massive retaliation for the killing of Supreme Leader Ayatollah Ali Khamenei by the United States and Israel.