The George Read II House in Old New Castle joins 13 other such landmarks in the state. Governor-elect John Carney, Sens. Tom Carper and Chris Coons and Rep. Lisa Blunt Rochester announced the landmark declaration this week.
The building was built between 1797 and 1804 and is a classic example of Federal-era architecture.
"The structure itself was built for George Read II, the son of the Delaware signer of the Declaration of Independence and Constitution," Read House Director Michele Anstine said.
She said the house offers a look back at a young America.
"It was a time of change. I think the house itself, the architecture of the house, really represents that time of change and the building of the new nation."
The house is the fourth National Historic Landmark to be designated in New Castle.
The building features extensive archives that document the house and its residents. It has been owned and operated by the Delaware Historical Society since 1975.