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The Middle East reacts to the U.S.-Israeli attacks on Iran which killed Supreme Leader Ayatollah Ali Khamenei.

NPR's Ayesha Rascoe speaks to Ray Takeyh, senior fellow for Middle East studies at the Council on Foreign Relations, about possible outcomes now that the U.S. and Israel have attacked Iran.

NPR's Ayesha Rascoe plays the puzzle with WXXI listener Jonathan Black and Weekend Edition Puzzlemaster Will Shortz.

The deaths of three U.S. service members mark the first American casualties since the start of operation "Epic Fury" on Saturday. President Trump said "there will likely be more" Americans killed.

The Iranian government has announced 40 days of mourning. The country's supreme leader was killed following an attack launched by the U.S. and Israel on Saturday against Iran.

Iran fired missiles at targets in Israel and Gulf Arab states Sunday after vowing massive retaliation for the killing of Supreme Leader Ayatollah Ali Khamenei by the United States and Israel.

Robert Harward is a former U.S. Navy Seal who grew up in Iran and led operations in the region. He speaks with host Mary Louise Kelly about this moment and what it means.

The United States and Israel launched military strikes against Iran overnight. NPR's Mary Louise Kelly discusses the attacks with NPR's Daniel Estrin and Greg Myre.

Khamenei, the Islamic Republic's second supreme leader, has been killed. He had held power since 1989, guiding Iran through difficult times — and overseeing the violent suppression of dissent.

In a scathing review, the top US medical journal's editorial board warned that the "destruction that Kennedy has wrought in 1 in office might take generations to repair."