Delaware Public Media

Delaware Tech students learn how to edit DNA

May 1, 2018

Some Delaware community college students received a hands-on introduction to gene editing this school year through a partnership with Christiana Care Health System.

 

Scientists, educators and students celebrated the success of the curriculum after two semesters, Tuesday.

Delaware Technical Community College students learned about gene editing using molecular scissors called CRISPR, and they applied their skills in the lab at the Stanton campus in Newark.

It’s an effort to introduce students to rapidly changing technology that can pave the way for how new cancer therapies are developed.

Student Darwin Gibbons says the courses were helpful in propelling him towards a career in forensics. He says one of the biggest takeaways is ethical concerns that revolve around using CRISPR.

“It’s not very hard to do, but to understand if you do gene editing on somebody that you can actually mess with their germline and that can mess with their offspring – there can be big hazards kind of like in the future with this," Gibbons said.  

Conversations about a gene editing curriculum started after Dr. Eric Kmiec, the director of Christiana Care’s  Gene Editing Institute, found CRISPR prototypes sitting in a freezer, and wanted to use them as a teaching tool. Christiana Care provided Delaware Tech with the technology to bring gene editing into the classroom.

"This is such a powerful tool, we have just touched the tip of the iceberg." -Dr. Eric Kmiec

“Most geneticists, most people, most doctors feel gene editing is the technology of the century,” Kmiec said. “It’s going to impact biomedical research. It’s going to impact how drugs are discovered, the development of new therapies for inherited diseases – sickle cell anemia, cancer.”

He continued, “This is such a powerful tool, we have just touched the tip of the iceberg. So we need lots more scientists and hopefully it will excite them to get into it.”  

The curriculum launched last fall after Delaware Tech and Christiana received a $1 million grant from the National Science Foundation. This past year, 17 students enrolled in the fall genetics course, and 15 enrolled in the spring 2018 molecular biology course – both at the Stanton campus. Thirteen students took the courses at Delaware Tech’s Owens campus.

  

Biology instructor John McDowell taught the courses and says students learned everything from how to use CRISPR to edit the genes in yeast, to editing DNA outside of bacteria and putting it back in the bacteria to see the changes.

Delaware Tech Science Educator Kristen Pisarcik talks about editing DNA outside of a cell and putting it back into bacteria to see if bacteria change color from blue to white.
Credit Katie Peikes / Delaware Public Media

“All the skills we’re teaching as part of the lab really relate to skills they need to have as a technician or as laboratory workers in the field,” McDowell said.

 

As for the curriculum, "I think it’s been hugely successful,” he said.

 

For students looking for careers in gene editing, there aren’t many in-state employers other than Christiana Care’s Gene Editing Institute. Kmiec says the institute employs 15 people, and they’re ready to add two or three more.   

 

According to the Delaware Department of Labor, there isn’t a classification for the gene editing industry, so it’s difficult to track what other companies and people statewide are doing work related to this field.

 

Kmiec says a lot of students can use the tools they’ve learned to help advance their education.

 

Delaware Tech plans to offer both the genetics and molecular biology courses again next year. McDowell says they may include new material from Christiana Care, as scientists’ work continues to evolve.